CuFeS₂ Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery.

ABSTRACT: CuFeS₂ chalcopyrite nanoparticles (NPs) can generate heat under exposure to near-infrared laser irradiation. Here, we develop a protocol to decorate the surface of CuFeS₂ NPs (13 nm) with a thermoresponsive (TR) polymer based on poly(ethylene glycol methacrylate) to combine heat-mediated drug delivery and photothermal heat damage. The resulting TR-CuFeS₂ NPs feature a small hydrodynamic size (∼75 nm), along with high colloidal stability and a TR transition temperature of 41 °C in physiological conditions. Remarkably, TR-CuFeS₂ NPs, when exposed to a laser beam (in the range of 0.5 and 1.5 W/cm²) at NP concentrations as low as 40-50 μg Cu/mL, exhibit a high heating performance with a rise in the solution temperature to hyperthermia ther

SUBMITTER: Conteh JS 

PROVIDER: S-EPMC10197081 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature