Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants.

ABSTRACT: We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed aptamers which can recognise all variants, from the original wild-type 'Wuhan' strain to Omicron, with high affinity (K_d values in the pM range).

SUBMITTER: Le TT 

PROVIDER: S-EPMC10197177 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature