Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction.

ABSTRACT:

Background

Human exposures to organophosphate flame retardants result from their use as additives in numerous consumer products. These agents are replacements for brominated flame retardants but have not yet faced similar scrutiny for developmental neurotoxicity. We examined a representative organophosphate flame retardant, triphenyl phosphate (TPP) and its potential effects on behavioral development and dopaminergic function.

Methods

Female Sprague-Dawley rats were given low doses of TPP (16 or 32 mg kg^-1  day^-1 ) via subcutaneous osmotic minipumps, begun preconception and continued into the early postnatal period. Offspring were administered a battery of behavioral tests from adolescence into adulthood, and littermates were used to evaluate dopaminerg

SUBMITTER: Hawkey AB 

PROVIDER: S-EPMC10197196 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature