Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor.

ABSTRACT:

Background

The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect. Sepsis-associated acute liver injury (SALI) is an independent risk factor for sepsis, which seriously affects the prognosis of sepsis. Studies have found that gut microbiota is closely related to SALI, and indole-3-propionic Acid (IPA) can activate Pregnane X receptor (PXR). However, the role of IPA and PXR in SALI has not been reported.

Methods

This study aimed to explore the association between IPA and SALI. The clinical data of SALI patients were collected and IPA level in feces was detected. The sepsis model was established in wild-type mice and PXR knockout

SUBMITTER: Wang S 

PROVIDER: S-EPMC10197241 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature