Perineural invasion affects prognosis of patients undergoing colorectal cancer surgery: a propensity score matching analysis.

ABSTRACT:

Background

Tumour perineural invasion (PNI) is a predictor of poor prognosis, but its effect on the prognosis of patients with colorectal cancer (CRC) has not yet been elucidated.

Methods

This retrospective study used propensity score matching (PSM). The clinical case data of 1470 patients with surgically treated stage I-IV CRC at Wuhan Union Hospital were collected. PSM was used to analyse and compare the clinicopathological characteristics, perioperative outcomes, and long-term prognostic outcomes of the PNI(+) and PNI(-) groups. The factors influencing prognosis were screened using Cox univariate and multivariate analyses.

Results

After PSM, 548 patients were included in the study (n = 274 in each group). Multifactorial analysis showed that neurological invasion wa

SUBMITTER: Qin L 

PROVIDER: S-EPMC10197328 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature