Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress.

ABSTRACT:

Background

Chronic stress exposure increases the risk of mental health problems such as anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling stress responses through communicating with multiple limbic structures, including the basolateral amygdala (BLA) and nucleus accumbens (NAc). However, considering the complex topographical organization of the mPFC neurons in different subregions (dmPFC vs. vmPFC) and across multiple layers (Layer II/III vs. Layer V), the exact effects of chronic stress on these distinct mPFC output neurons remain largely unknown.

Results

We first characterized the topographical organization of mPFC neurons projecting to BLA and NAc. Then, by using a typical mouse model of chronic restraint stress (CRS), we investigated th

SUBMITTER: Liu WZ 

PROVIDER: S-EPMC10197342 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature