Widespread sex-dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues.

ABSTRACT: The African turquoise killifish (Nothobranchius furzeri), the shortest-lived vertebrate that can be bred in captivity, is an emerging model organism to study vertebrate aging. Here we describe the first multi-tissue, single-cell gene expression atlas of female and male turquoise killifish tissues comprising immune and metabolic cells from the blood, kidney, liver, and spleen. We were able to annotate 22 distinct cell types, define associated marker genes, and infer differentiation trajectories. Using this dataset, we found pervasive sex-dimorphic gene expression across cell types, especially in the liver. Sex-dimorphic genes tended to be involved in processes related to lipid metabolism, and indeed, we observed clear differences in lipid storage in female vs. male turquoise k

SUBMITTER: Teefy BB 

PROVIDER: S-EPMC10197525 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature