Inferring Alzheimer's disease pathologic traits from clinical measures in living adults.

ABSTRACT:

Background

Alzheimer's disease neuropathologic changes (AD-NC) are important for identify people with high risk for AD dementia (ADD) and subtyping ADD.

Objective

Develop imputation models based on clinical measures to infer AD-NC.

Methods

We used penalized generalized linear regression to train imputation models for four AD-NC traits (amyloid-β, tangles, global AD pathology, and pathologic AD) in Rush Memory and Aging Project decedents, using clinical measures at the last visit prior to death as predictors. We validated these models by inferring AD-NC traits with clinical measures at the last visit prior to death for independent Religious Orders Study (ROS) decedents. We inferred baseline AD-NC traits for all ROS participants at study entry, and then tested if

SUBMITTER: Yang J 

PROVIDER: S-EPMC10197717 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature