C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape.

ABSTRACT: The accumulation of extracellular matrix (ECM) proteins in the liver leads to liver fibrosis and end-stage liver cirrhosis. C-C motif chemokine receptor 2 (CCR2) is an attractive target for treating liver fibrosis. However, limited investigations have been conducted to explore the mechanism by which CCR2 inhibition reduces ECM accumulation and liver fibrosis, which is the focus of this study. Liver injury and liver fibrosis were induced by carbon tetrachloride (CCl₄) in wild-type mice and Ccr2 knockout (Ccr2^-/-) mice. CCR2 was upregulated in murine and human fibrotic livers. Pharmacological CCR2 inhibition with cenicriviroc (CVC) reduced ECM accumulation and liver fibrosis in prevention and treatment administration. In single-cell RNA sequencing (scRNA-s

SUBMITTER: Guo Y 

PROVIDER: S-EPMC10197881 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature