Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice.

ABSTRACT:

Background

Previous studies have shown that secondary metabolites of Bacillus subtilis strain Z15 (BS-Z15) are effective in treating fungal infections in mice. To evaluate whether it also modulates immune function in mice to exert antifungal effects, we investigated the effect of BS-Z15 secondary metabolites on both the innate and adaptive immune functions of mice, and explored its molecular mechanism through blood transcriptome analysis.

Results

The study showed that BS-Z15 secondary metabolites increased the number of monocytes and platelets in the blood, improved natural killer (NK) cell activity and phagocytosis of monocytes-macrophages, increased the conversion rate of lymphocytes in the spleen, the number of T lymphocytes and the antibody production capacity of mice, a

SUBMITTER: Cao XY 

PROVIDER: S-EPMC10198031 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature