Role of the voltage‑gated sodium channel Nav1.6 in glioma and candidate drugs screening.

ABSTRACT: Gliomas remain a clinical challenge, common and fatal. Treatment of glioblastoma remains elusive, and researchers have focused on discovering new mechanisms and drugs. It has been well established that the expression of voltage‑gated sodium channels (VGSCs) is abnormally increased in numerous malignancies and, in general, is rarely expressed in the corresponding normal tissues. This suggests that ion channel activity appears to be associated with malignant progression of tumors. VGSCs remain largely unknown as to how their activity leads to an increase in cancer cell activity or invasiveness. Certain sodium ion channel subtypes (for instance, Nav1.5 and Nav1.7) are associated with metastasis and invasion in cancers including breast and colorectal cancers. A previous study by the authors ex

SUBMITTER: Ai Y 

PROVIDER: S-EPMC10198041 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature