Fecal microbiota transplantation for the maintenance of remission in patients with ulcerative colitis: A randomized controlled trial.

ABSTRACT:

Background

Fecal microbial transplantation (FMT) is a promising new method for treating active ulcerative colitis (UC), but knowledge regarding FMT for quiescent UC is scarce.

Aim

To investigate FMT for the maintenance of remission in UC patients.

Methods

Forty-eight UC patients were randomized to receive a single-dose FMT or autologous transplant via colonoscopy. The primary endpoint was set to the maintenance of remission, a fecal calprotectin level below 200 μg/g, and a clinical Mayo score below three throughout the 12-mo follow-up. As secondary endpoints, we recorded the patient's quality of life, fecal calprotectin, blood chemistry, and endoscopic findings at 12 mo.

Results

The main endpoint was achieved by 13 out of 24 (54%) patients in the FMT gro

SUBMITTER: Lahtinen P 

PROVIDER: S-EPMC10198050 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature