Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity.

ABSTRACT: Obesity is characterized by chronic, low-grade inflammation, which is driven by macrophage infiltration of adipose tissue. PPARγ is well established to have an anti-inflammatory function in macrophages, but the mechanism that regulates its function in these cells remains to be fully elucidated. PPARγ undergoes post-translational modifications (PTMs), including acetylation, to mediate ligand responses, including on metabolic functions. Here, we report that PPARγ acetylation in macrophages promotes their infiltration into adipose tissue, exacerbating metabolic dysregulation. We generated a mouse line that expresses a macrophage-specific, constitutive acetylation-mimetic form of PPARγ (K293Q^flox/flox:LysM-cre, mK293Q) to dissect the role of PPARγ acetylation in

SUBMITTER: Aaron N 

PROVIDER: S-EPMC10198133 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature