Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications.

ABSTRACT: Puberty is a major maturational event; its mechanisms and timing are driven by genetic determinants, but also controlled by endogenous and environmental cues. Substantial progress towards elucidation of the neuroendocrine networks governing puberty has taken place. However, key aspects of the mechanisms responsible for the precise timing of puberty and its alterations have only recently begun to be deciphered, propelled by epidemiological data suggesting that pubertal timing is changing in humans, via mechanisms that are not yet understood. By integrating basic and clinical data, we provide a comprehensive overview of current advances on the physiological basis of puberty, with a particular focus on the roles of kisspeptins and other central transmitters, the underlying molecular and endoc

SUBMITTER: Argente J 

PROVIDER: S-EPMC10198266 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature