Postoperative circulating tumor DNA testing based on tumor naive strategy after liver metastasis surgery in colorectal cancer patients.

ABSTRACT:

Objective

There is still a lack of highly sensitive methods for monitoring recurrence of colorectal cancer patients after liver metastasis surgery. The aim of this study was to evaluate the prognostic value of tumor-naive ctDNA detection after resection of colorectal liver metastases (CRLM).

Methods

Patients with resectable CRLM were prospectively enrolled. Based on the tumor-naive strategy, NGS panels containing 15 colorectal cancer hotspot mutated genes were used to detect ctDNA 3-6 weeks after surgery.

Results

A total of 67 patients were included in the study, and the positive rate of postoperative ctDNA was 77.6% (52/67). Patients with positive ctDNA had a significantly higher risk of recurrence after surgery (HR 3.596, 95% CI 1.479 to 8.744, P = 0.005), and a hig

SUBMITTER: Jiang H 

PROVIDER: S-EPMC10198283 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature