Post-treatment haemolysis is common following oral artemisinin combination therapy of uncomplicated malaria in travellers.

ABSTRACT:

Background

Artemisinin-based combination therapy (ACT) for the treatment of malaria is highly effective, well tolerated and safe. Episodes of delayed haemolysis occur in up to 57.9% of patients with severe malaria treated with intravenous artesunate, mainly caused by 'pitting' of infected red blood cells in the spleen and the delayed loss of these once-infected RBCs (oiRBCs). Several reports indicate that post-treatment haemolysis (PTH) also occurs in uncomplicated malaria treated with oral ACT, calling for systematic investigation.

Methods

A prospective observational study to identify the incidence of PTH after oral ACT, defined as increased lactate dehydrogenase activity and low haptoglobin level on Day 14 after treatment. Patients were enrolled at two study centres in Ger

SUBMITTER: Kurth F 

PROVIDER: S-EPMC10198431 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature