Genomic representation predicts an asymptotic host adaptation of bat coronaviruses using deep learning.

ABSTRACT:

Introduction

Coronaviruses (CoVs) are naturally found in bats and can occasionally cause infection and transmission in humans and other mammals. Our study aimed to build a deep learning (DL) method to predict the adaptation of bat CoVs to other mammals.

Methods

The CoV genome was represented with a method of dinucleotide composition representation (DCR) for the two main viral genes, ORF1ab and Spike. DCR features were first analyzed for their distribution among adaptive hosts and then trained with a DL classifier of convolutional neural networks (CNN) to predict the adaptation of bat CoVs.

Results and discussion

The results demonstrated inter-host separation and intra-host clustering of DCR-represented CoVs for six host types: Artiodactyla, Carnivora, Ch

SUBMITTER: Li J 

PROVIDER: S-EPMC10198438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature