Plasma proteome perturbation for CMV DNAemia in kidney transplantation.

ABSTRACT:

Background

Cytomegalovirus (CMV) infection, either de novo or as reactivation after allotransplantation and chronic immunosuppression, is recognized to cause detrimental alloimmune effects, inclusive of higher susceptibility to graft rejection and substantive impact on chronic graft injury and reduced transplant survival. To obtain further insights into the evolution and pathogenesis of CMV infection in an immunocompromised host we evaluated changes in the circulating host proteome serially, before and after transplantation, and during and after CMV DNA replication (DNAemia), as measured by quantitative polymerase chain reaction (QPCR).

Methods

LC-MS-based proteomics was conducted on 168 serially banked plasma samples, from 62 propensity score-matched kidney transplant recip

SUBMITTER: Sigdel TK 

PROVIDER: S-EPMC10198483 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature