Eleven-Year Outcomes of Deep Brain Stimulation in Early-Stage Parkinson Disease.

ABSTRACT:

Objective

The deep brain stimulation (DBS) in early-stage Parkinson's disease (PD) pilot clinical trial randomized 30 patients (Hoehn & Yahr II off; medication duration 0.5-4 years; without dyskinesia/motor fluctuations) to optimal drug therapy (ODT) (early ODT) or bilateral subthalamic nucleus (STN) DBS plus ODT (early DBS+ODT). This study aims to report the 11-year outcomes of patients who completed the DBS in early-stage PD pilot clinical trial.

Materials and methods

Attempts were made to contact all 29 subjects who completed the two-year trial to participate in an 11-year follow-up study. Mixed-effects models compared overall trend in outcomes for randomization groups (fixed-effects: assigned treatment, year, their interaction; random-effect: subject) to account for repe

SUBMITTER: Hacker ML 

PROVIDER: S-EPMC10198566 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature