The evolution of the discrete multirenculate kidney in mammals from ecological and molecular perspectives.

ABSTRACT: Mammals have developed different kinds of renal structures during evolution, yet the origin of the renal structural phenotypes and the molecular mechanisms underlying their adaptive evolution remains unclear. Here, we reconstructed the ancestral state of the renal structures across mammals and found that the unilobar kidney was the ancestral character in mammals. The subsequent correlation analyses between renal phenotypes and life history traits revealed that species with a larger body or in aquatic habitats tend to have evolved discrete multirenculate kidneys. To explore the molecular convergent mechanisms among mammals with this most distinct renal structure, the discrete multirenculate kidney, we used 45 genes related to duplex/multiplex kidney diseases to compare the evolutions of spe

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10198776 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature