The evolutionary dynamics history of canine distemper virus through analysis of the hemagglutinin gene during 1930-2020.

ABSTRACT: Canine distemper virus (CDV) is a lethal viral disease of carnivores which is considered to be a serious threat to domestic and wild species. Despite the widespread use of vaccines, CDV still occurs in vaccinated animals and current vaccines does not guarantee complete protection. In this study, a total of 286 hemagglutinin (H) gene sequences of the virus isolated in 25 countries during 90 years (1930-2020) were analyzed by Bayesian maximum likelihood analysis to estimate the population dynamics. We identified the most recent common ancestor (TMRCA) of the virus in 1868 in the USA which arrived in continental Europe in 1948, and from there, the virus spread rapidly to other continents. The Canidae family was identified as the original host as well as a source of the subsequent sprea

SUBMITTER: Wang H 

PROVIDER: S-EPMC10198785 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature