Loneliness and risk of all-cause, Alzheimer's, vascular, and frontotemporal dementia: a prospective study of 492,322 individuals over 15 years.

ABSTRACT:

Objectives

This study examined the association between loneliness and risk of incident all-cause dementia and whether the association extends to specific causes of dementia.

Design

Longitudinal.

Setting

Community.

Participants

Participants were from the UK Biobank (N = 492,322).

Intervention

None.

Measurements

Loneliness was measured with a standard item. The diagnosis of dementia was derived from health and death records, which included all-cause dementia and the specific diagnoses of Alzheimer's disease (AD), vascular dementia (VD), and frontotemporal dementia (FTD), over 15 years of follow-up.

Results

Feeling lonely was associated with a nearly 60% increased risk of all-cause dementia (HR = 1.59, 95% CI = 1.51-1.65; n = 7,4

SUBMITTER: Sutin AR 

PROVIDER: S-EPMC10198800 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature