The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer.

ABSTRACT: Immunotherapies targeting truly tumor-specific targets focus on the expansion and activation of T cells against neoantigens or oncogenic viruses. One target is the human papilloma virus type 16 (HPV16), responsible for several anogenital cancers and oropharyngeal carcinomas. Spontaneous and vaccine-induced HPV-specific T cells have been associated with better clinical outcome. However, the epitopes and restriction elements to which these T cells respond remained elusive. To identify CD8⁺ T cell epitopes in cultures of tumor infiltrating lymphocytes, we here used multimers and/or a functional screening platform exploiting single HLA class I allele-engineered antigen presenting cells. This resulted in the detection of 20 CD8⁺ T cell responses to 11 different endogenousl

SUBMITTER: Santegoets SJ 

PROVIDER: S-EPMC10198845 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature