Pharmacological management of youth with type 2 diabetes and diabetic kidney disease: a comprehensive review of current treatments and future directions.

ABSTRACT:

Introduction

Diabetic kidney disease (DKD) is a leading cause of mortality in people with type 2 diabetes (T2D), and over 50% of individuals with youth-onset T2D will develop DKD as a young adult. Diagnosis of early-onset DKD remains a challenge in young persons with T2D secondary to a lack of available biomarkers for early DKD, while the injuries may still be reversible. Furthermore, multiple barriers exist to initiate timely prevention and treatment strategies for DKD, including a lack of Food and Drug Administration approval of medications in pediatrics; provider comfort with medication prescription, titration, and monitoring; and medication adherence.

Areas covered

Therapies that have promise for slowing DKD progression in youth with T2D include metformin, renin-angioten

SUBMITTER: Tommerdahl KL 

PROVIDER: S-EPMC10198950 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature