Comparing the effects of four common drug classes on the progression of mild cognitive impairment to dementia using electronic health records.

ABSTRACT: The objective of this study was to investigate the potential association between the use of four frequently prescribed drug classes, namely antihypertensive drugs, statins, selective serotonin reuptake inhibitors, and proton-pump inhibitors, and the likelihood of disease progression from mild cognitive impairment (MCI) to dementia using electronic health records (EHRs). We conducted a retrospective cohort study using observational EHRs from a cohort of approximately 2 million patients seen at a large, multi-specialty urban academic medical center in New York City, USA between 2008 and 2020 to automatically emulate the randomized controlled trials. For each drug class, two exposure groups were identified based on the prescription orders documented in the EHRs following their MCI diagnosis.

SUBMITTER: Xu J 

PROVIDER: S-EPMC10199021 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature