Noradrenergic stimulation of α₁ adrenoceptors in the medial prefrontal cortex mediates acute stress-induced facilitation of seizures in mice.

ABSTRACT: Stress is one of the critical facilitators for seizure induction in patients with epilepsy. However, the neural mechanisms underlying this facilitation remain poorly understood. Here, we investigated whether noradrenaline (NA) transmission enhanced by stress exposure facilitates the induction of medial prefrontal cortex (mPFC)-originated seizures. In mPFC slices, whole-cell current-clamp recordings revealed that bath application of picrotoxin induced sporadic epileptiform activities (EAs), which consisted of depolarization with bursts of action potentials in layer 5 pyramidal cells. Addition of NA dramatically shortened the latency and increased the number of EAs. Simultaneous whole-cell and field potential recordings revealed that the EAs are synchronous in the mPFC local circuit. Terazos

SUBMITTER: Niitani K 

PROVIDER: S-EPMC10199052 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature