Refinement of saliva microRNA biomarkers for sports-related concussion.

ABSTRACT:

Background

Recognizing sport-related concussion (SRC) is challenging and relies heavily on subjective symptom reports. An objective, biological marker could improve recognition and understanding of SRC. There is emerging evidence that salivary micro-ribonucleic acids (miRNAs) may serve as biomarkers of concussion; however, it remains unclear whether concussion-related miRNAs are impacted by exercise. We sought to determine whether 40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact sports. Our goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of exercise.

Methods

This case-control study harmonized data from concussed and non-concussed

SUBMITTER: Hicks SD 

PROVIDER: S-EPMC10199136 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature