Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears.

ABSTRACT: Meniscus injuries are extremely common with approximately one million patients undergoing surgical treatment annually in the U.S. alone, but no regenerative therapy exist. Previously, we showed that controlled applications of connective tissue growth factor (CTGF) and transforming growth factor beta 3 (TGFβ3) via fibrin-based bio-glue facilitate meniscus healing by inducing recruitment and stepwise differentiation of synovial mesenchymal stem/progenitor cells. Here, we first explored the potential of genipin, a natural crosslinker, to enhance fibrin-based glue's mechanical and degradation properties. In parallel, we identified the harmful effects of lubricin on meniscus healing and investigated the mechanism of lubricin deposition on the injured meniscus surface. We found that the pre-depo

SUBMITTER: Tarafder S 

PROVIDER: S-EPMC10199165 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature