N-telopeptide as a potential diagnostic and prognostic marker for bone metastasis in human cancers: A meta-analysis.

ABSTRACT:

Purpose

Whether N-telopeptide of type I collagen (NTx) can be applied for diagnosis and prognostic prediction of bone metastasis in human cancers is still conflicting. This study aimed to investigate the diagnostic and prognostic value of NTx for cancer patients with bone metastasis.

Methods

Embase, PubMed, Chinese National Knowledge Infrastructure and Wanfang databases were retrieved to collect related publications. In diagnostic meta-analysis, the sensitivity (SEN) and specificity (SPE) were calculated. Hazard ratio (HR) with 95% confidence interval (95% CI) was used in the prognostic meta-analysis. Sensitivity and publication analyses were conducted for potential heterogeneity sources.

Results

The pooled SEN and SPE were 77% (72-81%) and 80% (75-84%) for 45

SUBMITTER: Li L 

PROVIDER: S-EPMC10199183 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature