Oxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina.

ABSTRACT: The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients, and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and pathological angiogenesis using the oxygen-induced retinopathy model. By matching lipid profiles to changes in mRNA transcriptome, we identified a lipid signature showing that pathological angiogenesis leads to intense lipid remodeling favoring pathways for neutral lipid synthesis, cholesterol import/export, and lipid droplet formation. Noteworthy, it also shows profound changes in pathways for long-chain fatty acid production, vital for retina homeostasis. The net result is accumulation of large quant

SUBMITTER: Inague A 

PROVIDER: S-EPMC10199268 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature