Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients.

ABSTRACT:

Background

Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug repositioning approaches may be employed for the development of new treatment strategies for Alzheimer's patients since an extensive amount of omics data has been generated during pre-clinical and clinical studies. However, targeting the most critical pathophysiological mechanisms and determining drugs with proper pharmacodynamics and good efficacy are equally crucial in drug repurposing and often imbalanced in Alzheimer's studies.

Methods

Here, we investigated central co-expressed genes upregulated in Alzheimer's disease to determine a proper therapeutic target. We backed our reasoning by checking the target gene's estimated non-

SUBMITTER: Bayraktar A 

PROVIDER: S-EPMC10199278 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature