High-quality, customizable heuristics for RNA 3D structure alignment.

ABSTRACT:

Motivation

Tertiary structure alignment is one of the main challenges in the computer-aided comparative study of molecular structures. Its aim is to optimally overlay the 3D shapes of two or more molecules in space to find the correspondence between their nucleotides. Alignment is the starting point for most algorithms that assess structural similarity or find common substructures. Thus, it has applications in solving a variety of bioinformatics problems, e.g. in the search for structural patterns, structure clustering, identifying structural redundancy, and evaluating the prediction accuracy of 3D models. To date, several tools have been developed to align 3D structures of RNA. However, most of them are not applicable to arbitrarily large structures and do not allow users to param

SUBMITTER: Zurkowski M 

PROVIDER: S-EPMC10199316 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature