Designing Artificial Metalloenzymes by Tuning of the Environment beyond the Primary Coordination Sphere.

ABSTRACT: Metalloenzymes catalyze a variety of reactions using a limited number of natural amino acids and metallocofactors. Therefore, the environment beyond the primary coordination sphere must play an important role in both conferring and tuning their phenomenal catalytic properties, enabling active sites with otherwise similar primary coordination environments to perform a diverse array of biological functions. However, since the interactions beyond the primary coordination sphere are numerous and weak, it has been difficult to pinpoint structural features responsible for the tuning of activities of native enzymes. Designing artificial metalloenzymes (ArMs) offers an excellent basis to elucidate the roles of these interactions and to further develop practical biological catalysts. In this review

SUBMITTER: Van Stappen C 

PROVIDER: S-EPMC10199331 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature