Assessment of Initial Depressive State and Pain Relief With Ketamine in Patients With Chronic Refractory Pain.

ABSTRACT:

Importance

Repeated ketamine administration is common in treatment-refractory chronic pain, but ketamine analgesic and antidepressant effects are poorly understood in patients with chronic pain with depression symptoms.

Objective

To determine clinical pain trajectories with repeated ketamine administrations, exploring whether ketamine dose and/or pretreatment depressive and/or anxiety symptoms may mediate pain relief.

Design, setting, and participants

This nationwide, multicenter, prospective cohort study included patients in France with treatment-refractory chronic pain who received repeated ketamine administration, over 1 year, according to ketamine use in their pain clinic. Data were collected from July 7, 2016, through September 21, 2017. Linear mixed models for r

SUBMITTER: Voute M 

PROVIDER: S-EPMC10199354 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature