Survival of children with trisomy 18 associated with the presence of congenital heart disease and intervention in the Republic of Korea.

ABSTRACT:

Background

Trisomy 18 syndrome (T18) is the second most common autosomal trisomy and has a high risk of fetal loss and stillbirth. Aggressive surgical treatments for the respiratory, cardiac, or digestive systems of patients with T18 were previously futile, while the results of recent studies are controversial. Over the past decade, there have been approximately 300,000 to 400,000 births annually in the Republic of Korea; however, there have been no nationwide studies on T18. This nationwide retrospective cohort study aimed to determine the prevalence of T18 in Korea and its prognosis according to the presence of congenital heart disease and relevant interventions.

Methods

This study utilized NHIS-registered data between 2008 and 2017. A child was defined as having T18 if th

SUBMITTER: Song IG 

PROVIDER: S-EPMC10199514 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature