Exposing new taxonomic variation with inflammation - a murine model-specific genome database for gut microbiome researchers.

ABSTRACT:

Background

The murine CBA/J mouse model widely supports immunology and enteric pathogen research. This model has illuminated Salmonella interactions with the gut microbiome since pathogen proliferation does not require disruptive pretreatment of the native microbiota, nor does it become systemic, thereby representing an analog to gastroenteritis disease progression in humans. Despite the value to broad research communities, microbiota in CBA/J mice are not represented in current murine microbiome genome catalogs.

Results

Here we present the first microbial and viral genomic catalog of the CBA/J murine gut microbiome. Using fecal microbial communities from untreated and Salmonella-infected, highly inflamed mice, we performed genomic reconstruction to determine the impacts on

SUBMITTER: Leleiwi I 

PROVIDER: S-EPMC10199544 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature