CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer (OC) has high mortality and poor prognosis for lacking of specific biomarkers and typical clinical symptoms in the early stage. CEBPG is an important regulator in tumor development, yet it is unclear exactly how it contributes to the progression of OC.

Methods

TCGA and tissue microarrays with immunohistochemical staining (IHC) were used to examine CEBPG expression in OC. A variety of in vitro assays were conducted, including colony formation, proliferation, migration, and invasion. The orthotopic OC mouse model was established for in vivo studies. Ferroptosis was detected by observing mitochondrial changes with electron microscopy, detecting ROS expression, and detecting cell sensitivity to drugs by CCK8 assay. The interaction between CEBPG and SLC7

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10199564 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature