The survival impact of adjuvant radiotherapy and chemotherapy in patients with non-endometrioid endometrial carcinomas: a PSM-IPTW analysis based on SEER database.

ABSTRACT:

Purpose

To investigate outcomes of adjuvant treatments for non-endometrioid endometrial carcinomas (NEEC), as previous studies are limited by its rarity and heterogeneity.

Patients and methods

Patients with endometrial serous carcinoma (SC), clear cell carcinoma (CCC) and carcinosarcoma were identified between 2004 and 2018 from SEER database. Propensity score matching (PSM) along with inverse probability treatment weighting (IPTW) technique were employed to balance confounding factors. Multivariate, exploratory subgroup and sensitivity analyses were conducted to evaluate the impact of adjuvant treatment on overall survival (OS) and cause-specific survival (CSS).

Results

The cohort comprised 5577 serous, 977 clear cell, and 959 carcinosarcomas. Combined chemotherapy a

SUBMITTER: Hao Z 

PROVIDER: S-EPMC10199615 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature