Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus.

ABSTRACT: Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modulating their functions via ionotropic and G-protein coupled mechanisms. GABAergic interneurons are critical for generation of coordinated network activity in both neonatal and adult brain, yet the role of interneuronal KARs in network synchronization remains unclear. Here, we show that GABAergic neurotransmission and spontaneous network activity is perturbed in the hippocampus of neonatal mice lacking GluK1 KARs selectively in GABAergic neurons. Endogenous activity of interneuronal GluK1 KARs maintains the frequency and duration of spontaneous neonatal network bursts and restrains their propagation through the hippocampal network. In adult male mice, the absence of GluK1

SUBMITTER: Ojanen S 

PROVIDER: S-EPMC10199616 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature