Network pharmacology and molecular docking study for biological pathway detection of cytotoxicity of the yellow jasmine flowers.

ABSTRACT:

Background

The yellow jasmine flower (Jasminum humile L.) is a fragrant plant belonging to the Oleaceae family with promising phytoconstituents and interesting medicinal uses. The purpose of this study was to characterize the plant metabolome to identify the potential bioactive agents with cytotoxic effects and the underlying mechanism of cytotoxic activity.

Methods

First, HPLC-PDA-MS/MS was used to identify the potential bioactive compounds in the flowers. Furthermore, we assessed the cytotoxic activity of the flower extract against breast cancer (MCF-7) cell line using MTT assay followed by the cell cycle, DNA-flow cytometry, and Annexin V-FITC analyses alongside the effect on reactive oxygen species (ROS). Finally, Network pharmacology followed by a molecular docking stud

SUBMITTER: El-Hawary SS 

PROVIDER: S-EPMC10199617 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature