Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID.

ABSTRACT:

Background

Damage to the cerebral vasculature can lead to vascular contributions to cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to neuropathology, including neuroinflammation and white matter lesions that are a hallmark of VCID. Mid-life metabolic disease (obesity, prediabetes, or diabetes) is a risk factor for VCID which may be sex-dependent (female bias).

Methods

We compared the effects of mid-life metabolic disease between males and females in a chronic cerebral hypoperfusion mouse model of VCID. C57BL/6J mice were fed a control or high fat (HF) diet starting at ~ 8.5 months of age. Three months after diet initiation, sham or unilateral carotid artery occlusion surgery (VCID model) was performed. Three months later, mice underwen

SUBMITTER: Abi-Ghanem C 

PROVIDER: S-EPMC10199629 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature