Prognostic value of 12-month response to therapy in pediatric patients with differentiated thyroid cancer.

ABSTRACT:

Purpose

In pediatric patients with differentiated thyroid cancer (DTC) we assessed the prognostic value of the 12-month response to therapy after initial treatment with surgery and radioactive iodine (RAI).

Methods

We retrospectively evaluated 94 pediatric patients with DTC, treated with surgery and RAI who were initially classified as low, intermediate or high risk of relapse of disease according to the American Thyroid Association (ATA) guidelines. Twelve months after RAI administration the response to therapy was assessed by serum thyroglobulin (Tg) measurement and neck ultrasound and patients were classified as having excellent response (ER) or no-ER.

Results

At the 12 months evaluation, 62 (66%) patients had ER and 32 (34%) no-ER. During a mean follow-up time of

SUBMITTER: Zampella E 

PROVIDER: S-EPMC10199830 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature