Sex differences in dementia with Lewy bodies: an imaging study of neurotransmission pathways.

ABSTRACT:

Purpose

Dementia with Lewy bodies (DLB) is characterized by a wide clinical and biological heterogeneity, with sex differences reported in both clinical and pathologically confirmed DLB cohorts. No research evidence is available on sex differences regarding molecular neurotransmission. This study aimed to assess whether sex can influence neurotransmitter systems in patients with probable DLB (pDLB).

Methods

We included 123 pDLB patients (male/female: 77/46) and 78 control subjects (male/female: 34/44) for comparison, who underwent ¹²³I-FP-CIT SPECT imaging. We assessed sex differences in the dopaminergic activity of the nigrostriatal and mesolimbic systems using regional-based and voxel-wise analyses of ¹²³I-FP-CIT binding. We tested whether sex-specifi

SUBMITTER: Boccalini C 

PROVIDER: S-EPMC10199852 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature