Validation of simplified uptake measures against dynamic Patlak K_i for quantification of lesional ⁸⁹Zr-Immuno-PET antibody uptake.

ABSTRACT:

Purpose

Positron emission tomography imaging of zirconium-89-labelled monoclonal antibodies (⁸⁹Zr-Immuno-PET) allows for visualisation and quantification of antibody uptake in tumours in vivo. Patlak linearization provides distribution volume (V_T) and nett influx rate (K_i) values, representing reversible and irreversible uptake, respectively. Standardised uptake value (SUV) and tumour-to-plasma/tumour-to-blood ratio (TPR/TBR) are often used, but their validity depends on the comparability of plasma kinetics and clearances. This study assesses the validity of SUV, TPR and TBR against Patlak K_i for quantifying irreversible ⁸⁹Zr-Immuno-PET uptake in tumours.

Methods

Ten patients received 37 MBq 10 mg ⁸⁹Zr-anti-EG

SUBMITTER: Wijngaarden JE 

PROVIDER: S-EPMC10199860 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature