A cycle-consistent adversarial network for brain PET partial volume correction without prior anatomical information.

ABSTRACT:

Purpose

Partial volume effect (PVE) is a consequence of the limited spatial resolution of PET scanners. PVE can cause the intensity values of a particular voxel to be underestimated or overestimated due to the effect of surrounding tracer uptake. We propose a novel partial volume correction (PVC) technique to overcome the adverse effects of PVE on PET images.

Methods

Two hundred and twelve clinical brain PET scans, including 50 ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG), 50 ¹⁸F-Flortaucipir, 36 ¹⁸F-Flutemetamol, and 76 ¹⁸F-FluoroDOPA, and their corresponding T1-weighted MR images were enrolled in this study. The Iterative Yang technique was used for PVC as a reference or surrogate of the ground truth for evaluation. A cycle-consis

SUBMITTER: Sanaat A 

PROVIDER: S-EPMC10199868 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature