A systematic review of the potential effects of medications and drugs of abuse on dopamine transporter imaging using [¹²³I]I-FP-CIT SPECT in routine practice.

ABSTRACT:

Purpose

In routine practice, dopamine transporter (DAT) imaging is frequently used as a diagnostic tool to support the diagnosis of Parkinson's disease or dementia with Lewy bodies. In 2008, we published a review on which medications and drugs of abuse may influence striatal [¹²³I]I-FP-CIT binding and consequently may influence the visual read of an [¹²³I]I-FP-CIT SPECT scan. We made recommendations on which drugs should be withdrawn before performing DAT imaging in routine practice. Here, we provide an update of the original work based on published research since 2008.

Methods

We performed a systematic review of literature without language restriction from January 2008 until November 2022 to evaluate the possible effects of medications and drugs of abu

SUBMITTER: Chahid Y 

PROVIDER: S-EPMC10199883 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature