Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees.

ABSTRACT: Nosema ceranae is an intracellular parasite invading the midgut of honeybees, which causes serious nosemosis implicated in honeybee colony losses worldwide. The core gut microbiota is involved in protecting against parasitism, and the genetically engineering of the native gut symbionts provides a novel and efficient way to fight pathogens. Here, using laboratory-generated bees mono-associated with gut members, we find that Snodgrassella alvi inhibit microsporidia proliferation, potentially via the stimulation of host oxidant-mediated immune response. Accordingly, N. ceranae employs the thioredoxin and glutathione systems to defend against oxidative stress and maintain a balanced redox equilibrium, which is essential for the infection process. We knock down the gene expression using nanopar

SUBMITTER: Lang H 

PROVIDER: S-EPMC10199888 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature