Identifying signatures of positive selection in human populations from North Africa.

ABSTRACT: Because of its location, North Africa (NA) has witnessed continuous demographic movements with an impact on the genomes of present-day human populations. Genomic data describe a complex scenario with varying proportions of at least four main ancestry components: Maghrebi, Middle Eastern-, European-, and West-and-East-African-like. However, the footprint of positive selection in NA has not been studied. Here, we compile genome-wide genotyping data from 190 North Africans and individuals from surrounding populations, investigate for signatures of positive selection using allele frequencies and linkage disequilibrium-based methods and infer ancestry proportions to discern adaptive admixture from post-admixture selection events. Our results show private candidate genes for selection in NA invo

SUBMITTER: Caro-Consuegra R 

PROVIDER: S-EPMC10199912 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature