Ginger essential oil and citral ameliorates atherosclerosis in ApoE^-/- mice by modulating trimethylamine-N-oxide and gut microbiota.

ABSTRACT: Recently, the role of the gut microbiota in diseases, including cardiovascular disease (CVD), has gained considerable research attention. Trimethylamine-N-oxide (TMAO), which is formed during ʟ-carnitine metabolism, promotes the formation of atherosclerotic plaques, causing thrombosis. Here, we elucidated the anti-atherosclerotic effect and mechanism of ginger (Zingiber officinale Roscoe) essential oil (GEO) and its bioactive compound citral in Gubra Amylin NASH (GAN) diet with ʟ-carnitine-induced atherosclerosis female ApoE^-/- mice. Treatment with GEO at both low and high doses and citral inhibited the formation of aortic atherosclerotic lesions, improved plasma lipid profile, reduced blood sugar, improved insulin resistance, decreased plasma TMAO levels, and inhibited plasma i

SUBMITTER: Panyod S 

PROVIDER: S-EPMC10199921 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature