Epigenome-wide association study of diabetic chronic kidney disease progression in the Korean population: the KNOW-CKD study.

ABSTRACT: Since the etiology of diabetic chronic kidney disease (CKD) is multifactorial, studies on DNA methylation for kidney function deterioration have rarely been performed despite the need for an epigenetic approach. Therefore, this study aimed to identify epigenetic markers associated with CKD progression based on the decline in the estimated glomerular filtration rate in diabetic CKD in Korea. An epigenome-wide association study was performed using whole blood samples from 180 CKD recruited from the KNOW-CKD cohort. Pyrosequencing was also performed on 133 CKD participants as an external replication analysis. Functional analyses, including the analysis of disease-gene networks, reactome pathways, and protein-protein interaction networks, were conducted to identify the biological mechanisms of

SUBMITTER: Sung HY 

PROVIDER: S-EPMC10199928 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature